Detection of Rare Somatic GNAS Mutation in McCune-Albright Syndrome Using a Novel Peptide Nucleic Acid Probe in a Single Tube

Detection of Rare Somatic GNAS Mutation in McCune-Albright Syndrome Using a Novel Peptide Nucleic Acid Probe in a Single Tube

McCune-Albright syndrome (MAS) is characterized by the triad of precocious puberty, café au lait pigmentation, and polyostotic fibrous dysplasia (FD) of bone, and is caused by post-zygotic somatic mutations—R201H or R201C—in the guanine nucleotide binding protein, alpha stimulating (GNAS) gene. In t...

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Bibliographic Details
Main Authors: Fu-Sung Lo, Tai-Long Chen, Chiuan-Chian Chiou
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
peptide nucleic acid probe
sensitive detection
McCune-Albright syndrome
GNAS mutation
Online Access:https://www.mdpi.com/1420-3049/22/11/1874

Internet

https://www.mdpi.com/1420-3049/22/11/1874

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