Environmental control of mammary carcinoma cell expansion by acidification and spheroid formation in vitro

Abstract Breast cancer is the leading cause of cancer death among women worldwide. Like other cancers, mammary carcinoma progression involves acidification of the tumor microenvironment, which is an important factor for cancer detection and treatment strategies. However, the effects of acidity on ma...

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Bibliographic Details
Main Authors: Ana Carolina Lima Ralph, Iuri Cordeiro Valadão, Elaine Cristina Cardoso, Vilma Regina Martins, Luanda Mara Silva Oliveira, Estela Maris Andrade Forell Bevilacqua, Murilo Vieira Geraldo, Ruy Gastaldoni Jaeger, Gary S. Goldberg, Vanessa Morais Freitas
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78989-6