Protective effects of PARP1-inhibitory compound in dry age-related macular degeneration

Protective effects of PARP1-inhibitory compound in dry age-related macular degeneration

Poly (ADP-ribose) polymerase 1 (PARP1)-dependent cell death in the retinal pigment epithelium (RPE) is implicated in dry age-related macular degeneration (AMD). Although PARP1 inhibitors are available for treating dry AMD, their delivery route is not ideal for patients. The aim of this study was to...

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Bibliographic Details
Main Authors: Jeongmin Ho, Ki-Hong Jang, Tae-Sung Koo, Changmin Park, Young-Hoon Kim, Juhee Lee, Eunhee Kim
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Dry AMD
PARP1
PARP1-inhibitory compound
RPE
Funduscopy
Electroretinogram
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220312336

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http://www.sciencedirect.com/science/article/pii/S0753332220312336

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