Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1

Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1

Objective: Monoacylglycerol acyltransferase (MGAT) enzymes catalyze the synthesis of diacylglycerol from monoacylglycerol. Previous work has suggested the importance of MGAT activity in the development of obesity-related hepatic insulin resistance. Indeed, antisense oligonucleotide (ASO)-mediated kn...

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Bibliographic Details
Main Authors: Andrew J. Lutkewitte, Jason M. Singer, Trevor M. Shew, Michael R. Martino, Angela M. Hall, Mai He, Brian N. Finck
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Molecular Metabolism
Subjects:
Monoacylglycerol acyltransferase
Insulin resistance
Antisense oligonucleotides
Interferon alpha/beta receptor 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000442

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http://www.sciencedirect.com/science/article/pii/S2212877821000442

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