The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease

The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease

Expression of the interleukin-1 receptor type I (IL-1RI) co-receptor Toll-like and interleukin-1 receptor regulator (TILRR) is significantly increased in blood monocytes following myocardial infarction and in the atherosclerotic plaque, whereas levels in healthy tissue are low. TILRR association wit...

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Bibliographic Details
Main Authors: Sarah A. Smith, PhD, Andriy O. Samokhin, PhD, Mabruka Alfadi, PhD, Emer C. Murphy, PhD, David Rhodes, MSc, W. Mike L. Holcombe, PhD, Endre Kiss-Toth, PhD, Robert F. Storey, BSc, BM, DM, Siu-Pok Yee, PhD, Sheila E. Francis, PhD, Eva E. Qwarnstrom, PhD
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:JACC: Basic to Translational Science
Subjects:
heparan sulfate proteoglycan
interleukin-1 receptor
IL-1RI
NF-κB
TILRR
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X1730133X

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http://www.sciencedirect.com/science/article/pii/S2452302X1730133X

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