Oxidative Stress Attenuates TLR3 Responsiveness and Impairs Anti-viral Mechanisms in Bronchial Epithelial Cells From COPD and Asthma Patients

Oxidative Stress Attenuates TLR3 Responsiveness and Impairs Anti-viral Mechanisms in Bronchial Epithelial Cells From COPD and Asthma Patients

COPD and asthma exacerbations are commonly triggered by rhinovirus infection. Potentially promoting exacerbations, impaired anti-viral signaling and attenuated viral clearance have been observed in diseased bronchial epithelium. Oxidative stress is a feature of inflammation in asthma and COPD and is...

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Bibliographic Details
Main Authors: Mandy Menzel, Sangeetha Ramu, Jenny Calvén, Beata Olejnicka, Asger Sverrild, Celeste Porsbjerg, Ellen Tufvesson, Leif Bjermer, Hamid Akbarshahi, Lena Uller
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
asthma
COPD
bronchial epithelium
oxidative stress
rhinovirus
interferon
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02765/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02765/full

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