Association of Transcriptomic Signatures of Inflammatory Response with Viral Control after Dendritic Cell-Based Therapeutic Vaccination in HIV-1 Infected Individuals

Association of Transcriptomic Signatures of Inflammatory Response with Viral Control after Dendritic Cell-Based Therapeutic Vaccination in HIV-1 Infected Individuals

Systems vaccinology has seldomly been used in therapeutic HIV-1 vaccine research. Our aim was to identify early gene ‘signatures’ that predicted virus load control after analytical therapy interruption (ATI) in participants of a dendritic cell-based HIV-1 vaccine trial (DCV2). mRNA and miRNA were ex...

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Bibliographic Details
Main Authors: Csaba Fehér, Roque Pastor-lbáñez, Lorna Leal, Montserrat Plana, Mireia Arnedo, Henk-Jan van den Ham, Arno C. Andeweg, Rob A. Gruters, Francisco Díez-Fuertes, José Alcamí, Patrick Aloy, Felipe García
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Vaccines
Subjects:
dendritic cell-based therapeutic HIV-1 vaccine
differential gene expression
mRNA
miRNA
gene set enrichment analysis
Online Access:https://www.mdpi.com/2076-393X/9/7/799

Internet

https://www.mdpi.com/2076-393X/9/7/799

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