Microfluidics in Sickle Cell Disease Research: State of the Art and a Perspective Beyond the Flow Problem

Microfluidics in Sickle Cell Disease Research: State of the Art and a Perspective Beyond the Flow Problem

Sickle cell disease (SCD) is the monogenic hemoglobinopathy where mutated sickle hemoglobin molecules polymerize to form long fibers under deoxygenated state and deform red blood cells (RBCs) into predominantly sickle form. Sickled RBCs stick to the vascular bed and obstruct blood flow in extreme co...

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Bibliographic Details
Main Authors: Anupam Aich, Yann Lamarre, Daniel Pereira Sacomani, Simone Kashima, Dimas Tadeu Covas, Lucimara Gaziola de la Torre
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
sickle microfluidics
sickle cell disease
exosomes
organ-on-chip
drug screening
cell–cell interactions
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.558982/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2020.558982/full

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