Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

Abstract Background Epigenome editing is expected to manipulate transcription and cell fates and to elucidate the gene expression mechanisms in various cell types. For functional epigenome editing, assessing the chromatin context-dependent activity of artificial epigenetic modifier is required. Resu...

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Bibliographic Details
Main Authors: Masahiro Okada, Mitsuhiro Kanamori, Kazue Someya, Hiroko Nakatsukasa, Akihiko Yoshimura
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Epigenetics & Chromatin
Subjects:
Treg
Foxp3
CRISPR
dCas9
TET1
p300
Online Access:http://link.springer.com/article/10.1186/s13072-017-0129-1

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http://link.springer.com/article/10.1186/s13072-017-0129-1

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