Multiple Interactions Between Cancer Cells and the Tumor Microenvironment Modulate TRAIL Signaling: Implications for TRAIL Receptor Targeted Therapy

Multiple Interactions Between Cancer Cells and the Tumor Microenvironment Modulate TRAIL Signaling: Implications for TRAIL Receptor Targeted Therapy

Tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL) signaling is far more complex than initially anticipated and can lead to either anti- or protumorigenic effects, hampering the successful clinical use of therapeutic TRAIL receptor agonists. Cell autonomous resistance mechanisms h...

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Bibliographic Details
Main Authors: Margot de Looff, Steven de Jong, Frank A. E. Kruyt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
TRAIL
TME
cytokines
cancer
immune suppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01530/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01530/full

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