Functional Block of Interleukin-6 Reduces a Bone Pain Marker but Not Bone Loss in Hindlimb-Unloaded Mice

Functional Block of Interleukin-6 Reduces a Bone Pain Marker but Not Bone Loss in Hindlimb-Unloaded Mice

Interleukin-6 (IL-6) is widely accepted to stimulate osteoclasts. Our aim in this study was to examine whether the inhibitory effect of IL-6 on bone loss and skeletal pain associated with osteoporosis in hindlimb-unloaded (HU) mice in comparison with bisphosphonate. Eight-week-old male ddY mice were...

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Bibliographic Details
Main Authors: Hiroki Wakabayashi, Gaku Miyamura, Nobuto Nagao, Sho Kato, Yohei Naito, Akihiro Sudo
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
osteoporosis
interleukin-6
hindlimb-unloading
osteoporotic pain
tail suspension
CGRP
Online Access:https://www.mdpi.com/1422-0067/21/10/3521

Internet

https://www.mdpi.com/1422-0067/21/10/3521

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