CyPPA, a positive SK3/SK2 modulator, reduces activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methylphenidate

CyPPA, a positive SK3/SK2 modulator, reduces activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methylphenidate

Dopamine (DA) containing midbrain neurons play critical roles in several psychiatric and neurological diseases, including schizophrenia and attention deficit hyperactivity disorder (ADHD), and the substantia nigra pars compacta neurons selectively degenerate in Parkinson’s disease. Pharmacological m...

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Bibliographic Details
Main Authors: Kjartan F. Herrik, John P Redrobe, Dorte eHolst, Charlotte eHougaard, Karin S. Nielsen, Alexander N. Nielsen, Huifang eJi, Nina M. Holst, Hanne B. Rasmussen, Elsebet Ø. Nielsen, Dorte eStrøbæk, Paul D. Shepard, Palle eChristophersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Pharmacology
Subjects:
Apamin
Immunohistochemistry
Dopamine release
KCa2
KCNN
mAHP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00011/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00011/full

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