Regulation of human Δ-6 desaturase gene transcription: identification of a functional direct repeat-1 element

The rate-limiting step in 20:4(n-6) and 22:6(n-3) synthesis is the desaturation of 18:2(n-6) and 18:3(n-3) by Δ-6 desaturase. In this report, we demonstrate that n-6 and n-3 PUFAs suppressed the hepatic expression of rodent Δ-6 desaturase by inhibiting the rate of Δ-6 desaturase gene transcription....

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Bibliographic Details
Main Authors: Chongren Tang, Hyekung P. Cho, Manabu T. Nakamura, Steven D. Clarke
Format: Article
Language:English
Published: Elsevier 2003-04-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520311585