Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling

Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling

Chlamydia trachomatis induces DNA double-strand breaks in host cells but simultaneously inhibits proper DNA damage response and repair mechanisms. This may render host cells prone to loss of genetic integrity and transformation. Here we show that C. trachomatis prevents activation of the key DNA dam...

Full description

Bibliographic Details
Main Authors: Yang Mi, Rajendra Kumar Gurumurthy, Piotr K. Zadora, Thomas F. Meyer, Cindrilla Chumduri
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mBio
Subjects:
DNA damage response
DNA double-strand breaks
ATM
PP2A
homologous recombination repair
infection
Online Access:https://doi.org/10.1128/mBio.01465-18

Internet

https://doi.org/10.1128/mBio.01465-18

Similar Items