Increased sensitivity to chemotherapy induced by CpG-ODN treatment is mediated by microRNA modulation.

Increased sensitivity to chemotherapy induced by CpG-ODN treatment is mediated by microRNA modulation.

We recently reported that peritumoral CpG-ODN treatment, activating TLR-9 expressing cells in tumor microenvironment, induces modulation of genes involved in DNA repair and sensitizes cancer cells to DNA-damaging cisplatin treatment. Here, we investigated whether this treatment induces modulation of...

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Bibliographic Details
Main Authors: Loris De Cecco, Martina Berardi, Michele Sommariva, Alessandra Cataldo, Silvana Canevari, Delia Mezzanzanica, Marilena V Iorio, Elda Tagliabue, Andrea Balsari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3590172?pdf=render

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http://europepmc.org/articles/PMC3590172?pdf=render

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