Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival

Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival

Glioblastomas (GBM) are the most aggressive form of primary brain tumors in humans. A key feature of malignant gliomas is their cellular heterogeneity. In particular, the presence of an undifferentiated cell population of defined Glioblastoma Stem cells (GSCs) was reported. Increased expression of a...

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Bibliographic Details
Main Authors: Ilaria Cristofaro, Francesco Alessandrini, Zaira Spinello, Claudia Guerriero, Mario Fiore, Elisa Caffarelli, Pietro Laneve, Luciana Dini, Luciano Conti, Ada Maria Tata
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
cancer stem cells
m2 muscarinic receptors
egfr
notch
cell cycle
apoptosis
Online Access:https://www.mdpi.com/2073-4409/9/3/657

Internet

https://www.mdpi.com/2073-4409/9/3/657

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