Silver-assisted gold-catalyzed formal synthesis of the anticoagulant Fondaparinux pentasaccharide
Despite strong demand for their clinical use, the synthesis of heparin oligosaccharides as anticoagulants remains challenging. Here, a mild and scalable formal synthesis of Fondaparinux pentasaccharide is presented through [Au]/[Ag]-catalyzed glycosidations.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-02-01
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| Series: | Communications Chemistry |
| Online Access: | https://doi.org/10.1038/s42004-021-00452-y |