Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB

Triptolide (TPL) inhibits the proliferation of a variety of cancer cells and has been proposed as an effective anticancer agent. In this study, we demonstrate that TPL downregulates HER2 protein expression in oral, ovarian, and breast cancer cells. It suppresses HER2 protein expression in a dose- an...

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Bibliographic Details
Main Authors: Chien-Chih Ou, Yuan-Wu Chen, Shih-Chung Hsu, Huey-Kang Sytwu, Shih-Hurng Loh, Jhy-Wei Li, Jah-Yao Liu
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2012/350239