Pyruvate carboxylase and cancer progression

Pyruvate carboxylase and cancer progression

Abstract Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. In nonmalignant tissue, PC plays an essential role in controlling whole-body energetics through regu...

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Bibliographic Details
Main Authors: Violet A. Kiesel, Madeline P. Sheeley, Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt, Dorothy Teegarden
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cancer & Metabolism
Subjects:
Pyruvate carboxylase
Metastasis
Energy metabolism
Online Access:https://doi.org/10.1186/s40170-021-00256-7

Internet

https://doi.org/10.1186/s40170-021-00256-7

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