Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency

Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency

The development of antibody-drug conjugates (ADCs) has significantly been advanced in the past decade given the improvement of payloads, linkers and conjugation methods. In particular, linker design plays a critical role in modulating ADC stability in the systemic circulation and payload release eff...

Full description

Bibliographic Details
Main Authors: Dian Su, Donglu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
linker design
stability
payload release
immolation
threshold dose
dose regimen
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.687926/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.687926/full

Similar Items