Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration

Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration

Mechanisms underlying α-synuclein (αSyn) mediated neurodegeneration are poorly understood. Intramuscular (IM) injection of αSyn fibrils in human A53T transgenic M83+/− mice produce a rapid model of α-synucleinopathy with highly predictable onset of motor impairment. Using varying doses of αSyn seeds...

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Bibliographic Details
Main Authors: Zachary A. Sorrentino, Yuxing Xia, Cory Funk, Cara J. Riffe, Nicola J. Rutherford, Carolina Ceballos Diaz, Amanda N. Sacino, Nathan D. Price, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Neurobiology of Disease
Subjects:
α-synuclein
Inflammation
Neurodegeneration
Prionoid transmission
RNAseq
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118305527

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http://www.sciencedirect.com/science/article/pii/S0969996118305527

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