GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling

GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling

Osteosarcoma is the most common primary bone malignancy in teenagers and continues to confer a generally poor prognosis due to its highly metastatic potential. Poor solubility in water and instability of curcumin limits its bioavailability for use in the adjuvant situation to improve the prognosis a...

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Bibliographic Details
Main Authors: Peace Wun-Ang Lu, Renn-Chia Lin, Jia-Sin Yang, Eric Wun-Hao Lu, Yi-Hsien Hsieh, Meng-Ying Tsai, Ko-Hsiu Lu, Shun-Fa Yang
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceuticals
Subjects:
GO-Y078
osteosarcoma
apoptosis
JNK
Online Access:https://www.mdpi.com/1424-8247/14/6/497

Internet

https://www.mdpi.com/1424-8247/14/6/497

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