Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids

Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids

L-bifunctional enzyme (Ehhadh) is part of the classical peroxisomal fatty acid β-oxidation pathway. This pathway is highly inducible via peroxisome proliferator-activated receptor α (PPARα) activation. However, no specific substrates or functions for Ehhadh are known, and Ehhadh knockout (KO) mice d...

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Bibliographic Details
Main Authors: Sander M. Houten, Simone Denis, Carmen A. Argmann, Yuzhi Jia, Sacha Ferdinandusse, Janardan K. Reddy, Ronald J.A. Wanders
Format: Article
Language:English
Published: Elsevier 2012-07-01
Series:Journal of Lipid Research
Subjects:
peroxisome
fatty acid oxidation
mouse models
omega oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520345065

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http://www.sciencedirect.com/science/article/pii/S0022227520345065

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