Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism.

Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism.

Subchondral bone modifications occur early in the development of osteoarthritis (OA). The level of bone resorption might impact cartilage remodeling. We therefore assessed the in vivo and in vitro effects of targeting bone resorption in OA and cartilage metabolism.OA was induced by meniscectomy (MNX...

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Main Authors: Thomas Funck-Brentano, Hilène Lin, Eric Hay, Marie-Dominique Ah Kioon, Corinne Schiltz, Didier Hannouche, Rémy Nizard, Frédéric Lioté, Philippe Orcel, Marie-Christine de Vernejoul, Martine Esther Cohen-Solal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3303845?pdf=render

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http://europepmc.org/articles/PMC3303845?pdf=render

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