Shared associations identify causal relationships between gene expression and immune cell phenotypes

Christiane Gasperi et al. used a shared association mapping approach to identify pairs of immune cell traits and gene expression traits showing shared genetic associations. Using polygenic risk score analysis and Mendelian randomization approaches, they find that while many such shared associations...

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Bibliographic Details
Main Authors: Christiane Gasperi, Sung Chun, Shamil R. Sunyaev, Chris Cotsapas
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01823-w