miR-150-Based RNA Interference Attenuates Tubulointerstitial Fibrosis through the SOCS1/JAK/STAT Pathway In Vivo and In Vitro

miR-150-Based RNA Interference Attenuates Tubulointerstitial Fibrosis through the SOCS1/JAK/STAT Pathway In Vivo and In Vitro

We investigated whether microRNA-150 (miR-150)-based RNA interference (RNAi) ameliorates tubular injury and tubulointerstitial fibrosis. Mice injected with folic acid developed tubulointerstitial fibrosis at day 30. miR-150 levels were increased at day 7 and peaked at day 30. At day 30, protein leve...

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Bibliographic Details
Main Authors: Junjun Luan, Jingqi Fu, Dongdong Wang, Congcong Jiao, Xiangfei Cui, Chengjie Chen, Dan Liu, Yixiao Zhang, Yanqiu Wang, Peter S.T. Yuen, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
RNAi
renal fibrosis
macrophages
SOCS1
folic acid
HK-2 cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120303206

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http://www.sciencedirect.com/science/article/pii/S2162253120303206

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