Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation

Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation

Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil. Variable (V) region genes undergo SHM to create amino acid substitutions that produce antibodies...

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Bibliographic Details
Main Authors: Ryan Costello, Jose F. Cantillo, Amy L. Kenter
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
Ig
somatic hypermutation
B cells
uracil DNA glycosylase
DT40
CRISPR
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02540/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02540/full

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