ITGA6+ Human Testicular Cell Populations Acquire a Mesenchymal Rather than Germ Cell Transcriptional Signature during Long-Term Culture

ITGA6+ Human Testicular Cell Populations Acquire a Mesenchymal Rather than Germ Cell Transcriptional Signature during Long-Term Culture

Autologous spermatogonial stem cell transplantation is an experimental technique aimed at restoring fertility in infertile men. Although effective in animal models, in vitro propagation of human spermatogonia prior to transplantation has proven to be difficult. A major limiting factor is endogenous...

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Bibliographic Details
Main Authors: Robert B. Struijk, Callista L. Mulder, Saskia K. M. van Daalen, Cindy M. de Winter-Korver, Aldo Jongejan, Sjoerd Repping, Ans M. M. van Pelt
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
fertility preservation
spermatogonia
stem cells
bulk transcriptome
germ cells
cell culture
Online Access:https://www.mdpi.com/1422-0067/21/21/8269

Internet

https://www.mdpi.com/1422-0067/21/21/8269

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