Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis

A wide range of genetic mouse models is available to help researchers dissect human disease mechanisms. Each type of model has its own distinctive characteristics arising from the nature of the introduced mutation, as well as from the specific changes to the gene of interest. Here, we review the cur...

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Bibliographic Details
Main Authors: Francesca De Giorgio, Cheryl Maduro, Elizabeth M. C. Fisher, Abraham Acevedo-Arozena
Format: Article
Language:English
Published: The Company of Biologists 2019-01-01
Series:Disease Models & Mechanisms
Subjects:
ALS
ENU
Online Access:http://dmm.biologists.org/content/12/1/dmm037424