A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis

A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis

Abstract Germline mutations in Mir96, one of three co-expressed polycistronic miRNA genes (Mir96, Mir182, Mir183), cause hereditary hearing loss in humans and mice. Transgenic FVB/NCrl- Tg(GFAP-Mir183,Mir96,Mir182)MDW1 mice (Tg1MDW), which overexpress this neurosensory-specific miRNA cluster in the...

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Bibliographic Details
Main Authors: Michael D. Weston, Shikha Tarang, Marsha L. Pierce, Umesh Pyakurel, Sonia M. Rocha-Sanchez, JoAnn McGee, Edward J. Walsh, Garrett A. Soukup
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-21811-1

Internet

https://doi.org/10.1038/s41598-018-21811-1

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