Orexin modulates behavioral fear expression through the locus coeruleus

Vigilance involves the activation of orexinergic neurons in the lateral hypothalamus (LH-ox). Here the authors report the functional role of a monosynaptically connected circuit with orexinergic neurons connected to noradrenergic neurons in the locus coeruleus which target lateral amygdala neurons a...

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Bibliographic Details
Main Authors: Shingo Soya, Tohru M. Takahashi, Thomas J. McHugh, Takashi Maejima, Stefan Herlitze, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01782-z