A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models

A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models

Estrogens regulate numerous pathophysiological processes, mainly by binding to and activating estrogen receptor (ER)α and ERβ. Increasing amounts of evidence have recently demonstrated that G-protein coupled receptor 30 (GPR30; also known as GPER) is also involved in diverse biological responses to...

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Bibliographic Details
Main Authors: Rosamaria Lappano, Camillo Rosano, Assunta Pisano, Maria Francesca Santolla, Ernestina Marianna De Francesco, Paola De Marco, Vincenza Dolce, Marco Ponassi, Lamberto Felli, Grazia Cafeo, Franz Heinrich Kohnke, Sergio Abonante, Marcello Maggiolini
Format: Article
Language:English
Published: The Company of Biologists 2015-10-01
Series:Disease Models & Mechanisms
Subjects:
Breast cancer
Calixpyrroles
Cancer-associated fibroblasts
Estrogen
GPR30/GPER
Signal transduction
Online Access:http://dmm.biologists.org/content/8/10/1237

Internet

http://dmm.biologists.org/content/8/10/1237

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