Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

The transcription factor ISL1 is thought to be key for conveying the multipotent and proliferative properties of cardiac precursor cells. Here, we investigate its function upon cardiac induction of human embryonic stem cells. We find that ISL1 does not stabilize the transient cardiac precursor cell...

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Bibliographic Details
Main Authors: Roberto Quaranta, Jakob Fell, Frank Rühle, Jyoti Rao, Ilaria Piccini, Marcos J Araúzo-Bravo, Arie O Verkerk, Monika Stoll, Boris Greber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
human embryonic stem cells
directed cardiac differentiation
cardiac subtype specification
Islet-1
Online Access:https://elifesciences.org/articles/31706

Internet

https://elifesciences.org/articles/31706

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