Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease

Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease

Viruses are underrepresented as targets in pharmacological screening efforts, given the difficulties of devising suitable cell-based and biochemical assays. In this study we found that a pre-fractionated organic extract of the Red Sea sponge Amphimedon chloros was able to inhibit the West Nile Virus...

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Bibliographic Details
Main Authors: Aubrie O’Rourke, Stephan Kremb, Brendan M. Duggan, Salim Sioud, Najeh Kharbatia, Misjudeen Raji, Abdul-Hamid Emwas, William H. Gerwick, Christian R. Voolstra
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
halitoxin
antiviral
Red Sea
bioprospecting
West Nile Virus
NS3 protease
High-Content Screening (HCS)
Online Access:http://www.mdpi.com/1420-3049/23/6/1472

Internet

http://www.mdpi.com/1420-3049/23/6/1472

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