Case Report: Severe Complement-Mediated Thrombotic Microangiopathy in IgG4-Related Disease Secondary to Anti-Factor H IgG4 Autoantibodies

Case Report: Severe Complement-Mediated Thrombotic Microangiopathy in IgG4-Related Disease Secondary to Anti-Factor H IgG4 Autoantibodies

ObjectiveTo first describe and estimate the potential pathogenic role of Ig4 autoantibodies in complement-mediated thrombotic microangiopathy (TMA) in a patient with IgG4-related disease (IgG4-RD).MethodsThis study is a case report presenting a retrospective review of the patient’s medical chart. Pl...

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Bibliographic Details
Main Authors: Gautier Breville, Ido Zamberg, Salima Sadallah, Caroline Stephan, Belen Ponte, Jörg D. Seebach
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
thrombotic microangiopathy
atypical hemolytic uremic syndrome
IgG4-related disease
antibodies
complement factor H-related protein
complement factor H
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.604759/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.604759/full

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