Aerobic Cytotoxicity of Aromatic <i>N-</i>Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1)
Derivatives of tirapazamine and other heteroaromatic <i>N-</i>oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities, which are typically attributed to bioreductive activation and free radical generation. In this work, we aimed to clarify the role of NAD(P)H:quin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/22/8754 |