CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions

CXCL9-Derived Peptides Differentially Inhibit Neutrophil Migration In Vivo through Interference with Glycosaminoglycan Interactions

Several acute and chronic inflammatory diseases are driven by accumulation of activated leukocytes due to enhanced chemokine expression. In addition to specific G protein-coupled receptor-dependent signaling, chemokine–glycosaminoglycan (GAG) interactions are important for chemokine activity in vivo...

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Bibliographic Details
Main Authors: Vincent Vanheule, Daiane Boff, Anneleen Mortier, Rik Janssens, Björn Petri, Elzbieta Kolaczkowska, Paul Kubes, Nele Berghmans, Sofie Struyf, Andreas J. Kungl, Mauro Martins Teixeira, Flavio Almeida Amaral, Paul Proost
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
chemokine
CXCL9
glycosaminoglycan
neutrophil
anti-inflammatory
gout
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00530/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00530/full

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