Learning from failure - rationale and design for a study about discontinuation of randomized trials (DISCO study)

Learning from failure - rationale and design for a study about discontinuation of randomized trials (DISCO study)

<p>Abstract</p> <p>Background</p> <p>Randomized controlled trials (RCTs) may be discontinued because of apparent harm, benefit, or futility. Other RCTs are discontinued early because of insufficient recruitment. Trial discontinuation has ethical implications, because pa...

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Bibliographic Details
Main Authors: Kasenda Benjamin, von Elm Erik B, You John, Blümle Anette, Tomonaga Yuki, Saccilotto Ramon, Amstutz Alain, Bengough Theresa, Meerpohl Jörg, Stegert Mihaela, Tikkinen Kari A O, Neumann Ignacio, Carrasco-Labra Alonso, Faulhaber Markus, Mulla Sohail, Mertz Dominik, Akl Elie A, Bassler Dirk, Busse Jason W, Ferreira-González Ignacio, Lamontagne Francois, Nordmann Alain, Rosenthal Rachel, Schandelmaier Stefan, Sun Xin, Vandvik Per O, Johnston Bradley C, Walter Martin A, Burnand Bernard, Schwenkglenks Matthias, Bucher Heiner C, Guyatt Gordon H, Briel Matthias
Format: Article
Language:English
Published: BMC 2012-08-01
Series:BMC Medical Research Methodology
Subjects:
Randomized controlled trial
Trial discontinuation
Slow recruitment
Ethics committees
Trial protocols
Online Access:http://www.biomedcentral.com/1471-2288/12/131

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http://www.biomedcentral.com/1471-2288/12/131

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