Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge

Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge

Abstract Background The increasing risk of obesity and diabetes among other metabolic disorders are the consequence of shifts in dietary patterns with high caloric-content food intake. We previously reported that megalin regulates energy homeostasis using blood-brain barrier (BBB) endothelial megali...

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Bibliographic Details
Main Authors: Fernando Bartolome, Desiree Antequera, Macarena de la Cueva, Marcos Rubio-Fernandez, Nerea Castro, Consuelo Pascual, Antoni Camins, Eva Carro
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
Megalin
Leptin
Obesity
High-fat diet
Mitochondrial biogenesis
Online Access:https://doi.org/10.1186/s12974-020-1702-2

Internet

https://doi.org/10.1186/s12974-020-1702-2

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