Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells

Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells

The vast majority (>90%) of glioblastoma (GBM) patients belong to the isocitrate dehydrogenase 1 wild type (IDH1WT) group which exhibits a poor prognosis with a median survival of less than 15 months. This study demonstrated numerous immunosuppressive genes as well as β-catenin gene, pivotal for...

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Bibliographic Details
Main Authors: Dandan Fan, Qi Yue, Jian Chen, Cong Wang, Ruilin Yu, Ziyi Jin, Shujie Yin, Qinyue Wang, Luo Chen, Xueling Liao, Chengyuan Peng, Jianpin Zhang, Zhonglian Cao, Ying Mao, Ruimin Huang, Liang Chen, Cong Li
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
wnt/β-catenin
idh1-wildtype glioblastoma
microglia
phenotypic polarization
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1932061

Internet

http://dx.doi.org/10.1080/2162402X.2021.1932061

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