The dysregulation of the hypothalamic–pituitary–adrenal axis in diet-induced prediabetic male Sprague Dawley rats

The dysregulation of the hypothalamic–pituitary–adrenal axis in diet-induced prediabetic male Sprague Dawley rats

Abstract Background Altered function of the hypothalamic–pituitary–adrenal (HPA) axis in type 2 diabetic patients, a condition preceded by pre-diabetes, has been shown to increase the risk of depression as well as cause downstream effects resulting in upregulation of gluconeogenesis and dyslipidemia...

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Bibliographic Details
Main Authors: Palesa Mosili, Bongeka Cassandra Mkhize, Phikelelani Ngubane, Ntethelelo Sibiya, Andile Khathi
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Nutrition & Metabolism
Subjects:
Prediabetes
High-fat high-carbohydrate diet
Hypothalamic–pituitary–adrenal axis
Cortisol
Corticosterone
Stress
Online Access:https://doi.org/10.1186/s12986-020-00532-1

Internet

https://doi.org/10.1186/s12986-020-00532-1

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