Cell cycle accumulation of the proliferating cell nuclear antigen PCN-1 transitions from continuous in the adult germline to intermittent in the early embryo of C. elegans

Cell cycle accumulation of the proliferating cell nuclear antigen PCN-1 transitions from continuous in the adult germline to intermittent in the early embryo of C. elegans

Abstract Background The proliferating cell nuclear antigen (PCNA or PCN-1 in C. elegans), an essential processivity factor for DNA polymerase δ, has been widely used as a marker of S-phase. In C. elegans early embryos, PCN-1 accumulation is cyclic, localizing to the nucleus during S-phase and the cy...

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Bibliographic Details
Main Authors: Zuzana Kocsisova, Kerry Kornfeld, Tim Schedl
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Developmental Biology
Subjects:
PCNA
S-phase
C. elegans
Germline
Cell cycle
pcn-1
Online Access:http://link.springer.com/article/10.1186/s12861-018-0171-7

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http://link.springer.com/article/10.1186/s12861-018-0171-7

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