Biological Effect of Single or Combined Pharmacological Therapy Using Alendronate and Simvastatin on Implant Osseointegration: An In Vivo Study in Healthy and Osteoporotic Rat Models

Biological Effect of Single or Combined Pharmacological Therapy Using Alendronate and Simvastatin on Implant Osseointegration: An In Vivo Study in Healthy and Osteoporotic Rat Models

To evaluate peri-implant bone formation following single or combined systemic administration of alendronate and simvastatin in healthy and osteoporotic rats, eighty female Wistar rats were ovariectomized (n = 40) or sham-operated (n = 40). At six weeks, implants were placed in femoral condyles. Then...

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Bibliographic Details
Main Authors: Amani M. Basudan, Marwa Y. Shaheen, Abdurahman A. Niazy, Jeroen J.J.P. van den Beucken, John A. Jansen, Hamdan S. Alghamdi
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Applied Sciences
Subjects:
dental implants
osseointegration
osteoporosis
alendronate
simvastatin
animal model
Online Access:https://www.mdpi.com/2076-3417/10/12/4298

Internet

https://www.mdpi.com/2076-3417/10/12/4298

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