Tissue Distribution and Receptor Activation by Somapacitan, a Long Acting Growth Hormone Derivative

Tissue Distribution and Receptor Activation by Somapacitan, a Long Acting Growth Hormone Derivative

Somapacitan is a long-acting, once-weekly, albumin-binding growth hormone (GH) derivative. The reversible albumin-binding properties leads to prolonged circulation half-life. Here, we investigated and compared somapacitan with human GH on downstream receptor signaling in primary hepatocytes and hepa...

Full description

Bibliographic Details
Main Authors: Maj Petersen, Prafull S. Gandhi, Jens Buchardt, Tomas Alanentalo, Johannes Josef Fels, Nils Langeland Johansen, Peter Helding-Kvist, Knud Vad, Peter Thygesen
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
somapacitan
human growth hormone
receptor signaling
p-stat5 activation
biodistribution
fluorescence molecular tomography
light-sheet fluorescence microscopy
proximal epiphysis
Online Access:https://www.mdpi.com/1422-0067/21/4/1181

Internet

https://www.mdpi.com/1422-0067/21/4/1181

Similar Items