Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family.

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family plays a central role in antigenic variation and cytoadhesion of P. falciparum infected erythrocytes. PfEMP1 proteins/var genes are classified into three main subfamilies (UpsA, UpsB, and UpsC) that are hypothesized to have diff...

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Bibliographic Details
Main Authors: Joel H Janes, Christopher P Wang, Emily Levin-Edens, Inès Vigan-Womas, Micheline Guillotte, Martin Melcher, Odile Mercereau-Puijalon, Joseph D Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3088720?pdf=render