Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network

Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network

Abstract Background MYO1C, an actin-based motor protein, is involved in the late stages of autophagosome maturation and fusion with the lysosome. The molecular mechanism by which MYO1C regulates autophagosome-lysosome fusion remains largely unclear. Methods Western blotting was used to determine the...

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Bibliographic Details
Main Authors: Yanhao Zhang, Xiuxing Jiang, Qin Deng, Ziyi Gao, Xiangyu Tang, Ruoqiu Fu, Jinjiao Hu, Yunong Li, Lirong Li, Ning Gao
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Autophagy/Mitophagy
Cepharanthine (CEP)
MYO1C
F-actin
Autophagosome-lysosome fusion
Online Access:http://link.springer.com/article/10.1186/s13046-019-1449-8

Internet

http://link.springer.com/article/10.1186/s13046-019-1449-8

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