Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice

Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice

Food allergy is an emerging epidemic, and the underlying mechanisms are not well defined partly due to the lack of robust adjuvant free experimental models of dietary antigen sensitization. As housing mice at thermoneutrality (Tn) - the temperature of metabolic homeostasis (26–30°C) – has been shown...

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Bibliographic Details
Main Authors: Taeko K. Noah, Jee-Boong Lee, Christopher A. Brown, Amnah Yamani, Sunil Tomar, Varsha Ganesan, Rodney D. Newberry, Gary B. Huffnagle, Senad Divanovic, Simon P. Hogan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
food sensitization
mouse models
antigen passage
thermoneutral conditions
food allergy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.636198/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.636198/full

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