Design and rationale of the Procalcitonin Antibiotic Consensus Trial (ProACT), a multicenter randomized trial of procalcitonin antibiotic guidance in lower respiratory tract infection

Design and rationale of the Procalcitonin Antibiotic Consensus Trial (ProACT), a multicenter randomized trial of procalcitonin antibiotic guidance in lower respiratory tract infection

Abstract Background Overuse of antibiotics is a major public health problem, contributing to growing antibiotic resistance. Procalcitonin has been reported to be commonly elevated in bacterial, but not viral infection. Multiple European trials found procalcitonin-guided care reduced antibiotic use i...

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Bibliographic Details
Main Authors: David T. Huang, Derek C. Angus, Chung-Chou H. Chang, Yohei Doi, Michael J. Fine, John A. Kellum, Octavia M. Peck-Palmer, Francis Pike, Lisa A. Weissfeld, Jonathan Yabes, Donald M. Yealy, on behalf of the ProACT Investigators
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Emergency Medicine
Subjects:
Procalcitonin
Biomarkers
Respiratory tract infections
Clinical trial
Anti-bacterial agents
Methods (MeSH)
Online Access:http://link.springer.com/article/10.1186/s12873-017-0138-1

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http://link.springer.com/article/10.1186/s12873-017-0138-1

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