CUG-BP and 3'UTR sequences influence PARN-mediated deadenylation in mammalian cell extracts

Several mRNAs have been shown to exhibit distinct patterns of poly(A) shortening prior to their decay in vivo. In this study, we show that individual transcripts also demonstrate distinct patterns of deadenylation in in vitro systems derived from HeLa and Jurkat T cell cytoplasmic extracts. The majo...

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Bibliographic Details
Main Authors: Karen C.M. Moraes, Carol J. Wilusz, Jeffrey Wilusz
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2007-01-01
Series:Genetics and Molecular Biology
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400024