Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion

Role of Dsg1- and Dsg3-Mediated Signaling in Pemphigus Autoantibody-Induced Loss of Keratinocyte Cohesion

Pemphigus is an autoimmune dermatosis in which mucocutaneous blisters are induced primarily by autoantibodies against Desmoglein (Dsg) 1 and 3. Pemphigus vulgaris (PV) usually is associated with autoantibodies against Dsg3 whereas pemphigus foliaceus (PF) patients present autoantibodies against Dsg1...

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Bibliographic Details
Main Authors: Elias Walter, Franziska Vielmuth, Marie-Therès Wanuske, Matthias Seifert, Robert Pollmann, Rüdiger Eming, Jens Waschke
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
pemphigus
keratinocytes
desmoglein
signaling
CRISPR/Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01128/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01128/full

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